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Myocardial ischaemia in patients with peripheral arterial disease
Author(s) -
Svensson Per,
De Faire Ulf,
Niklasson U.,
Östergren Jan
Publication year - 2007
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2007.00710.x
Subject(s) - medicine , dipyridamole , st depression , cardiology , peripheral , perfusion , depression (economics) , ischemia , ambulatory , st segment , anesthesia , myocardial infarction , economics , macroeconomics
Summary Aim: To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group. Methods: Ninety‐nine male patients with PAD and 94 age‐ and sex‐matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc‐99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48‐h ambulatory ECG (AECG)‐monitoring (43 controls). Results: Thirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively ( P <0·01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST‐depression in AECG in comparison with two episodes in two of 42 control subjects ( P = 0·07). Out of 13 patients with ST‐depression episodes only three had reversible ischaemia in MPS. Conclusion: Most PAD patients with episodes of ST‐segment depression have no reversible ischaemia as assessed with dipyridamole‐stress MPS. Episodes of ST‐segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.