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Cardiac pumping capability in patients with peripheral vascular disease
Author(s) -
Hodges L. D.,
Sandercock G. R. H.,
Das S. K.,
Brodie D. A.
Publication year - 2006
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2006.00673.x
Subject(s) - medicine , claudication , peripheral , cardiology , ambulatory , cardiac output , intermittent claudication , blood pressure , cardiorespiratory fitness , vo2 max , vascular disease , heart rate , arterial disease
Summary Introduction: Peripheral vascular disease (PVD) is a condition characterized by atherosclerotic occlusive disease of the lower extremities, low functional capacity and low exercise tolerance. Less empirical data are available concerning the cardiovascular response to maximum exercise tests in patients with PVD. The purpose of this study was to examine cardiovascular variables in patients with peripheral vascular disease. Methods: Fifty patients (67 ± 9 years) completed an incremental exercise test (2 min stages, 3·2 km h −1 , with increases of 2% every 2 min) to maximum claudication pain. Maximal oxygen consumption () was assessed on a breath‐by‐breath basis by online expiratory gas analysis (CardiO 2 , Medical Graphics Co.). Blood pressure was recorded at peak exercise. Following a 30‐min rest period, patients exercised at the highest level attained during the first test and cardiac output () was measured using the exponential non‐invasive rebreathing method. Cardiac power output peak (CPO peak ) in Watts (W), was then computed. Results: Mean ± SD values were; 13·85 ± 4·14 ml kg min −1 ; maximal walk time 357 ± 227 s; peak mean arterial pressure 127 ± 15 mmHg; 9·8 ± 2·39 (l min −1 ); CPO 2·86 ± 0·87 W. Conclusion: Patients with peripheral vascular disease demonstrate attenuated levels of cardiovascular capacity. This group of patients should be given exercise therapy in order to improve cardiovascular status and ambulatory function.