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Parathyroid scintigraphy during hypocalcaemia in primary hyperparathyroidism
Author(s) -
Øgard Christina G.,
Vestergaard Henrik,
Thomsen Jørn B.,
Jakobsen Henrik,
Almdal Thomas,
Nielsen Steen L.
Publication year - 2005
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2005.00604.x
Subject(s) - medicine , primary hyperparathyroidism , scintigraphy , parathyroid adenoma , technetium (99mtc) sestamibi , hyperparathyroidism , nuclear medicine , parathyroid neoplasm , radiology , pertechnetate , thyroid , perfusion
Summary Background: Minimally invasive parathyroid surgery in patients with primary hyperparathyroidism (PHPT) demands high imaging accuracy. By increasing blood flow to the parathyroid adenoma before injection of a perfusion marker, we intended to improve the parathyroid scintigraphy. We have named the technique stimulated parathyroid scintigraphy (SPS). Methods: Twenty minutes after injection of 100 MBq 99m Tc‐pertechnetate a thyroid scintigram was performed in 25 patients with PHPT. During the thyroid scintigraphy sodium citrate was infused which lowered plasma calcium by a mean of 14 ± 1·3%. Then 700 MBq 99m Tc‐sestamibi was injected and another scintigram of the neck was obtained. Perchlorate was given at the end of the sestamibi scintigram to increase the wash‐out of 99m Tc‐pertechnetate from the thyroid gland, and after 2 h a delayed scintigram was obtained. A subtraction of the thyroid scintigram from the initial sestamibi scintigram was performed. The results of SPS and a conventional 99m Tc‐sestamibi dual‐phase parathyroid scintigraphy were compared with the operative findings. In nine patients the parathyroid adenoma was also localized with ultrasound and the flow pattern before and after citrate infusion was visualized with Doppler technique. Results: Eighty‐eight per cent of the adenomas were localized correctly with the SPS technique compared with 62% at the conventional parathyroid scintigraphy. Tissue perfusion of the nine adenomas increased after citrate infusion. Conclusions: SPS has a high accuracy and it is easy to perform. If only subtraction SPS is performed the whole examination can be completed within an hour, which is acceptable for same day surgery.