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Regional blood flow during hyperoxic haemodilution
Author(s) -
Meier Jens,
Pape Andreas,
Kleen Martin,
Hutter Jörg,
Kemming Gregor,
Habler Oliver
Publication year - 2005
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2005.00603.x
Subject(s) - medicine , cardiac output , pancreas , cardiac index , skeletal muscle , blood flow , kidney , cardiology , hemodynamics
Summary Background: Ventilation with pure oxygen (hyperoxic ventilation, HV) increases arterial oxygen content (CaO 2 ). However HV induces arteriolar constriction and thus potentially affects O 2 supply. We therefore investigated the effects of HV on regional blood flow (RBF) and O 2 supply of different vital organs during moderate normovolaemic anaemia. Methods: Twenty‐two anaesthetized dogs were haemodiluted under normoxia (i.e. FiO 2 = 0·21) to a target haemoglobin concentration (Hb) of 7 g dl −1 and were subsequently ventilated with pure O 2 . RBF was determined by use of the radioactive microspheres method in the myocardium, kidney, skeletal muscle, liver, intestine, stomach, and pancreas at Hb = 7 g dl −1 and after subsequent initiation of HV. RBF in proportion to cardiac output (RBF relative ), the variation coefficient of RBF (VC) and regional O 2 supply (rDO 2 ) were calculated. Results: Initiation of HV at Hb = 7·0 ± 0·3 g dl −1 reduced cardiac index (−17%) as well as RBF within the myocardium (−21%), pancreas (−25%), and skeletal muscle (−25%), whereas renal, hepatic, and intestinal RBF remained unchanged. Consequently RBF relative of the latter organs increased. Heterogeneity of RBF was marginally affected by HV. Conclusion: The initiation of HV during moderate normovolaemic anaemia (Hb =7 g dl −1 ) was accompanied by RBF redistribution with preference for renal, hepatic and intestinal O 2 supply. Cardiac, pancreatic and muscular O 2 supply decreased, however without any critical restriction of organ function.