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Bone infection in patients suspected of complicating osteomyelitis: the diagnostic value of dual isotope bone‐granulocyte scintigraphy
Author(s) -
Buhl Thora,
Stentzer Kim,
Hede Adam,
Kjær Andreas,
Hesse Birger
Publication year - 2005
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2004.00581.x
Subject(s) - medicine , osteomyelitis , scintigraphy , granulocyte , bone scintigraphy , osteitis , erythrocyte sedimentation rate , radiology , nuclear medicine , surgery
Summary Aim: The purpose of this study was to evaluate the diagnostic value of dual isotope bone‐granulocyte scintigraphy in patients with known bone pathology clinically suspected of osteomyelitis, i.e. complicating osteomyelitis, using per‐operative bacterial culture from bone as reference. Methods: Simultaneous dual isotope bone‐granulocyte scintigraphic images were obtained in 42 consecutive patients in whom conventional X‐ray, erythrocyte sedimentation rate, and C‐reactive protein were also available. 99m Tc MDP bone and 111 In labelled granulocyte imaging was obtained simultaneously. The images were interpreted as positive for osteomyelitis if regions of interests of pathologic 111 In granulocyte accumulation included 99m Tc MDP activity on the bone images (except in the spine). Results: The sensitivity, specificity, and accuracy were 84, 71 and 79%, respectively, for simultaneous, dual isotope bone‐granulocyte scintigraphy, higher than the other diagnostic parameters. Conclusion: Simultaneous bone‐granulocyte scintigraphy is a valuable diagnostic tool in diagnosing osteomyelitis complicating other bone pathology with or without soft‐tissue infection.