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Ambulatory combined pH, bile and manometric monitoring of the oesophagus in asymptomatic healthy volunteers
Author(s) -
Freedman Jacob,
Lindqvist Madeleine,
Melcher Anders,
Granström Lars,
Näslund Erik
Publication year - 2004
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/j.1475-097x.2004.00573.x
Subject(s) - medicine , ambulatory , asymptomatic , peristalsis , bilirubin , reflux , gastroenterology , percentile , disease , statistics , mathematics
Summary Background: With the development of sophisticated equipment ambulatory studies of oesophageal motor function, pH and bilirubin have gained in popularity. The aim of the study was to present reference values for combined 24 h pH, bilirubin and manometric measurements of the oesophagus. Methods: Twenty‐six (15 male) healthy volunteers without symptoms of gastro‐oesophageal reflux underwent a 24‐h ambulatory oesophageal combined three‐channel pressure, acid and bilirubin detection. Results: The subjects were studied for a median of 20 h (16–22). The median per cent time with pH < 4 for the whole measured time was 3·1 (0·8–14; 5 and 95 percentiles). Bile was detected for a median of 0·05% (0·0–8·5; 5 and 95 percentiles) of the time. Eighty‐one per cent of the contractions were peristaltic, 55% of which were complete. Of these, 53% had a pressure over 30 mmHg at all three pressure points, giving an efficient peristalsis in a median of 29% (13–46; 5 and 95 percentiles) of all registered contractile patterns. No difference between the genders could be observed. Conclusions: This study provides normative data for ambulatory oesophageal manometry, pH and bilirubin studies that can be used for comparing with patients with disease.