Open AccessHost cell factor 1 inhibits SKN‐1 to modulate oxidative stress responses in Caenorhabditis elegans
Author(s) -
Rizki Gizem,
Picard Colette Lafontaine,
Pereyra Charles,
Lee Siu Sylvia
Publication year - 2012
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2012.00831.x
Subject(s) - caenorhabditis elegans , biology , transcription factor , microbiology and biotechnology , regulator , longevity , oxidative stress , context (archaeology) , genetics , conserved sequence , gene , biochemistry , peptide sequence , paleontology
Summary Host cell factor‐1 (HCF‐1) is a conserved regulator of the longevity and stress response functions of DAF‐16/FOXO. SKN‐1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro‐longevity factor. Here, we demonstrate that SKN‐1 contributes to the enhanced oxidative stress resistance incurred by hcf‐1 mutation in C. elegans . HCF‐1 prevents the nuclear accumulation of SKN‐1 and represses the transcriptional activation of SKN‐1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context‐specific regulatory relationship between two highly conserved longevity and stress response factors HCF‐1 and SKN‐1.