Open AccessThe dynamin‐related protein DRP‐1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity
Author(s) -
Yang Christine C.,
Chen Diana,
Lee Siu Sylvia,
Walter Ludivine
Publication year - 2011
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2011.00711.x
Subject(s) - caenorhabditis elegans , biology , dynamin , longevity , mitochondrial fission , microbiology and biotechnology , mitochondrion , yeast , model organism , insulin receptor , insulin , genetics , endocytosis , gene , receptor , insulin resistance
Summary Here, we report that inactivation of the Caenorhabditis elegans dynamin‐related protein DRP‐1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.