Open AccessResistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice
Author(s) -
Miller Richard A.,
Dolan David,
Han Melissa,
Kohler William,
Schacht Jochen
Publication year - 2011
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2010.00668.x
Subject(s) - fibroblast , biology , skin aging , hydrogen peroxide , hearing loss , ageing , dermal fibroblast , cell culture , microbiology and biotechnology , audiology , genetics , dermatology , biochemistry , medicine
Summary Those mice whose skin‐derived primary fibroblast cell lines resist lethal injury induced by hydrogen peroxide or UV light show lower age‐related decline in hearing. Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice.