Open AccessOxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway
Author(s) -
Williams David S.,
Cash Alan,
Hamadani Lara,
Diemer Tanja
Publication year - 2009
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2009.00527.x
Subject(s) - biology , caenorhabditis elegans , ampk , citrate synthase , longevity , citric acid cycle , metabolite , metabolome , biochemistry , kinase , microbiology and biotechnology , protein kinase a , metabolism , genetics , enzyme , gene
Summary Reduced dietary intake increases lifespan in a wide variety of organisms. It also retards disease progression. We tested whether dietary supplementation of citric acid cycle metabolites could mimic this lifespan effect. We report that oxaloacetate supplementation increased lifespan in Caenorhabditis elegans . The increase was dependent on the transcription factor, FOXO/DAF‐16, and the energy sensor, AMP‐activated protein kinase, indicating involvement of a pathway that is also required for lifespan extension through dietary restriction. These results demonstrate that supplementation of the citric acid cycle metabolite, oxaloacetate, influences a longevity pathway, and suggest a tractable means of introducing the health‐related benefits of dietary restriction.