Open AccessCalorie restriction alters mitochondrial protein acetylation
Author(s) -
Schwer Bjoern,
Eckersdorff Mark,
Li Yu,
Silva Jeffrey C.,
Fermin Damian,
Kurtev Martin V.,
Giallourakis Cosmas,
Comb Michael J.,
Alt Frederick W.,
Lombard David B.
Publication year - 2009
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2009.00503.x
Subject(s) - acetylation , biology , calorie restriction , mitochondrion , adaptation (eye) , lysine , mitochondrial dna , genetics , microbiology and biotechnology , biochemistry , gene , amino acid , neuroscience , endocrinology
Summary Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue‐specific fashion. Via large‐scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acetylation during CR. Mitochondrial acetylation changes may play an important role in the pro‐longevity CR response.