Open AccessThe overexpression of major antioxidant enzymes does not extend the lifespan of mice
Author(s) -
Pérez Viviana I.,
Van Remmen Holly,
Bokov Alex,
Epstein Charles J.,
Vijg Jan,
Richardson Arlan
Publication year - 2009
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2008.00449.x
Subject(s) - superoxide dismutase , catalase , antioxidant , enzyme , biology , hydrogen peroxide , reactive oxygen species , superoxide , biochemistry , dismutase , transgene , microbiology and biotechnology , gene
Summary We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.