Open AccessMarkers of cellular senescence in zero hour biopsies predict outcome in renal transplantation
Author(s) -
Koppelstaetter Christian,
Schratzberger Gabriele,
Perco Paul,
Hofer Johannes,
Mark Walter,
Öllinger Robert,
Oberbauer Rainer,
Schwarz Christoph,
Mitterbauer Christa,
Kainz Alexander,
Karkoszka Henryk,
Wiecek Andrzej,
Mayer Bernd,
Mayer Gert
Publication year - 2008
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2008.00398.x
Subject(s) - cdkn2a , creatinine , senescence , telomere , biology , transplantation , medicine , predictive marker , renal function , oncology , endocrinology , cancer , gene , genetics
Summary Although chronological donor age is the most potent predictor of long‐term outcome after renal transplantation, it does not incorporate individual differences of the aging‐process itself. We therefore hypothesized that an estimate of biological organ age as derived from markers of cellular senescence in zero hour biopsies would be of higher predictive value. Telomere length and mRNA expression levels of the cell cycle inhibitors CDKN2A (p16INK4a) and CDKN1A (p21WAF1) were assessed in pre‐implantation biopsies of 54 patients and the association of these and various other clinical parameters with serum creatinine after 1 year was determined. In a linear regression analysis, CDKN2A turned out to be the best single predictor followed by donor age and telomere length. A multiple linear regression analysis revealed that the combination of CDKN2A values and donor age yielded even higher predictive values for serum creatinine 1 year after transplantation. We conclude that the molecular aging marker CDKN2A in combination with chronological donor age predict renal allograft function after 1 year significantly better than chronological donor age alone.