Open AccessApolipoprotein D is involved in the mechanisms regulating protection from oxidative stress
Author(s) -
Ganfornina Maria D.,
Do Carmo Sonia,
Lora Jose M.,
TorresSchumann Sonia,
Vogel Marci,
Allhorn Maria,
González Constancio,
Bastiani Michael J.,
Rassart Eric,
Sanchez Diego
Publication year - 2008
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2008.00395.x
Subject(s) - biology , oxidative stress , neurodegeneration , lipocalin , function (biology) , apolipoprotein b , lipid peroxidation , central nervous system , microbiology and biotechnology , neuroscience , endocrinology , medicine , disease , cholesterol
Summary Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila , Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up‐regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids.