Open AccessApolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner
Author(s) -
Burgos Javier S.,
Ramirez Carlos,
Sastre Isabel,
Valdivieso Fernando
Publication year - 2007
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2007.00332.x
Subject(s) - biology , genotype , herpes simplex virus , apolipoprotein e , virology , allele , transmission (telecommunications) , pathogenesis , disease , virus , immunology , genetics , gene , medicine , electrical engineering , engineering
Summary There is growing evidence that herpes simplex virus type 1 (HSV‐1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV‐1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.