Open AccessLoss of pregnancy‐associated plasma protein A extends lifespan in mice
Author(s) -
Conover Cheryl A.,
Bale Laurie K.
Publication year - 2007
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2007.00328.x
Subject(s) - biology , longevity , pregnancy associated plasma protein a , endocrinology , endocrine system , pregnancy , medicine , regulator , andrology , physiology , hormone , genetics , fetus , gene , first trimester
Summary Genetic deletion in mice of pregnancy‐associated plasma protein A (PAPP‐A), a recently identified metalloproteinase in the insulin‐like growth factor system, extends by 30–40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP‐A as a critical regulator of lifespan and age‐related diseases, and suggest PAPP‐A as a possible target to promote longevity.