Open AccessRemodeling chromatin for senescence
Author(s) -
Adams Peter D.
Publication year - 2007
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2007.00313.x
Subject(s) - biology , senescence , cellular senescence , chromatin remodeling , chromatin , microbiology and biotechnology , computational biology , genetics , dna , phenotype , gene
Summary Cellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co‐workers describe new insights into the protein complexes that regulate these changes in chromatin structure.