Open AccessLong‐lived dwarf mice: are bile acids a longevity signal?
Author(s) -
Gems David
Publication year - 2007
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2007.00309.x
Subject(s) - xenobiotic , biology , longevity , nuclear receptor , farnesoid x receptor , drug metabolism , mutant , metabolism , genetics , ecology , biochemistry , gene , enzyme , transcription factor
Summary Pathways that control aging act via regulated biochemical processes, among which metabolism of xenobiotics (potentially harmful chemical agents encountered as environmental toxicants, for example, drugs, or produced internally) is one possible candidate. A new study of long‐lived Ghrhr mutant mice reports that increased bile acid levels activate xenobiotic metabolism via the nuclear receptor, farnesoid X receptor. This increases resistance to xenobiotic stress, possibly contributing to longevity.