Open AccessSerotonin receptors antagonistically modulate Caenorhabditis elegans longevity
Author(s) -
Murakami Hana,
Murakami Shin
Publication year - 2007
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2007.00303.x
Subject(s) - biology , serotonin , serotonin transporter , longevity , 5 ht receptor , serotonin plasma membrane transport proteins , neurotransmitter , endocrinology , receptor , genetics , medicine
Summary The neurotransmitter serotonin has been implicated in affecting the variation of longevity in natural Drosophila populations and age‐related diseases in mammals. Based on these observations, it has been predicted that serotonin signal, perhaps at levels of serotonin biosynthesis, may control lifespan. Here, we investigated a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes. Despite this prediction, mutations in the serotonin biosynthesis genes had little or modest effects on lifespan, while the mod‐5 mutation with increased availability of serotonin caused a modest life‐shortening effect. In contrast, a deletion mutation of the ser‐1 serotonin receptor gene increased longevity by up to 46%, likely through the insulin/insulin‐like growth factor 1 pathway. This result suggests an interaction between the serotonin pathway and the insulin/insulin‐like growth factor 1 pathway. A deletion mutation of another serotonin receptor gene, ser‐4 , shortened early to mid lifespan. The results suggest that serotonin signal antagonistically modulates longevity through different serotonin receptors. This study may indicate serotonin receptors as a potential target for antigeric interventions.