Open AccessStress, social rank and leukocyte telomere length
Author(s) -
Lansdorp Peter M.
Publication year - 2006
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2006.00247.x
Subject(s) - telomere , biology , genetics , attrition , cell , telomere binding protein , dna , gene , dna binding protein , transcription factor , medicine , dentistry
Summary Blood leukocytes are a heterogeneous mixture of cell types whose telomere lengths differ greatly, reflecting variation in stem cell turnover and recruitment, expansion and replacement of more mature cell types as well as variable telomere loss and telomere repair. These differences in cell and telomere length dynamics, together with the evidence that telomere length is influenced strongly by genetic polymorphisms, greatly complicate the interpretation of claims that socio‐economic status modulates the rate of telomere attrition.