Open AccessMurine myeloid dendritic cell‐dependent toll‐like receptor immunity is preserved with aging
Author(s) -
Tesar Bethany M.,
Walker Wendy E.,
Unternaehrer Julia,
Joshi Nikhil S.,
Chandele Anmol,
Haynes Laura,
Kaech Susan,
Goldstein Daniel R.
Publication year - 2006
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2006.00245.x
Subject(s) - biology , myeloid , immune system , immunology , innate immune system , acquired immune system , toll like receptor , priming (agriculture) , dendritic cell , immunity , bone marrow , microbiology and biotechnology , botany , germination
Summary The immune response is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this interaction is unclear. Addressing this fundamental question will be critical for the development of effective vaccines for the rapidly rising older subpopulation that manifests increased prevalence of malignancies and infections. Therefore, we undertook the current study to investigate whether aging impairs toll‐like receptor (TLR) function in myeloid dendritic cells and whether this leads to reduced T‐cell priming. Our results demonstrate that innate TLR immune priming function of myeloid bone marrow derived and splenic dendritic cells (DC) is preserved with aging using both allogeneic and infectious murine experimental systems. In contrast, aging impairs in vitro and in vivo intrinsic T‐cell function. Therefore, our results demonstrate that myeloid DCs manifest preserved TLR‐mediated immune responses with aging. However, aging critically impairs intrinsic adaptive T‐cell function.