Open AccessModulation of the age‐related nuclear factor‐κB (NF‐κB) pathway by hesperetin
Author(s) -
Kim Ji Young,
Jung Kyung Jin,
Choi Jae Sue,
Chung Hae Young
Publication year - 2006
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2006.00233.x
Subject(s) - biology , hesperetin , nf κb , nfkb1 , modulation (music) , microbiology and biotechnology , transcription factor , genetics , signal transduction , biochemistry , gene , physics , antioxidant , flavonoid , acoustics
Summary Nuclear factor‐κB (NF‐κB), a redox‐sensitive transcription factor, plays an important role in the aging process. Thus, developing and identifying specific components that modulate NF‐κB without adverse side‐effects would be of major importance. Hesperetin, a flavanone abundant in citrus fruits, has a variety of pharmacological properties being antioxidant, cholesterol‐lowering, and anti‐inflammatory. In this study, we investigated how hesperetin fed to 6‐ and 24‐month‐old rats modulates NF‐κB in their kidneys. Results showed that hesperetin suppressed NF‐κB activation and related gene expressions. An even more interesting finding is that hesperetin suppressed NF‐κB through four signal transduction pathways, NIK/IKK, ERK, p38, and JNK. Further evidence showed the remarkable efficacy of hesperetin to suppress the translocation of Trx/Ref‐1, indicating its beneficial effect on the redox status. The most significant findings of the current study report new information on the use of hesperetin as a potential anti‐aging agent.