Open AccessNitrones as therapeutics in age‐related diseases
Author(s) -
Floyd Robert A.
Publication year - 2006
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2006.00189.x
Subject(s) - biology , nitrone , bioinformatics , pharmacology , computational biology , neuroscience , cancer research , biochemistry , cycloaddition , catalysis
Summary Age‐related diseases deprive individuals of a higher quality of life and therefore therapeutics for their treatment provide significant potential. An overview of the observations of nitrones as potential therapeutics in several age‐related diseases is presented. Treatment of acute ischemic stroke is one condition where a nitrone (NXY‐059) is in late phase 3 clinical trials now. Also presented is a summary of the most recent work we have accomplished on the anticancer activity of the nitrones in a hepatocellular carcinoma. The mechanistic basis of action of these compounds in several animal models is not yet understood at the molecular levels; however, it does appear clear that their anti‐inflammatory properties are central to their action, which is based on their ability to down‐regulate exacerbated signal transduction processes.