Open AccessMetabolism, physiology and stress defense in three aging Ins/IGF‐1 mutants of the nematode Caenorhabditis elegans
Author(s) -
Houthoofd Koen,
Fidalgo Manuel A.,
Hoogewijs David,
Braeckman Bart P.,
Lenaerts Isabelle,
Brys Kristel,
Matthijssens Filip,
De Vreese Annemie,
Van Eygen Sylvie,
Muñoz Manuel J.,
Vanfleteren Jacques R.
Publication year - 2005
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1111/j.1474-9726.2005.00150.x
Subject(s) - caenorhabditis elegans , biology , mutant , microbiology and biotechnology , insulin like growth factor , nematode , metabolism , genetics , growth factor , gene , endocrinology , ecology , receptor
Summary The insulin/insulin‐like growth factor‐1 (Ins/IGF‐1) pathway regulates the aging rate of the nematode Caenorhabditis elegans . We describe other features of the three Ins/IGF‐1 mutants daf‐2 , age‐1 and aap‐1 . We show that the investigated Ins/IGF‐1 mutants all have a reduced body volume, reduced reproductive capacity, increased ATP concentrations and an elevated stress resistance. We also observed that heat production is lower in these mutants, although the respiration rate was similar or higher compared with wild‐type individuals, suggesting a metabolic shift in these mutants.