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Photo‐damage protective effect of two facial products, containing a unique complex of Dead Sea minerals and Himalayan actives
Author(s) -
Wineman Eitan,
PortugalCohen Meital,
Soroka Yoram,
Cohen Dror,
Schlippe Gerrit,
Voss Werner,
Brenner Sarah,
Milner Yoram,
Hai Noam,
Ma’or Zeevi
Publication year - 2012
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/j.1473-2165.2012.00625.x
Subject(s) - wrinkle , human skin , skin aging , apoptosis , epidermis (zoology) , cytokine , necrosis , dermatology , medicine , tumor necrosis factor alpha , skin repair , chemistry , pharmacology , pathology , biology , immunology , wound healing , biochemistry , anatomy , gerontology , genetics
Summary Background Skin appearance is badly affected when exposed to solar UV rays, which encourage physiological and structural cutaneous alterations that eventually lead to skin photo‐damage. Aims To test the capability of two facial preparations, extreme day cream (EXD) and extreme night treatment (EXN), containing a unique complex of Dead Sea water and three Himalayan extracts, to antagonize biological effects induced by photo‐damage. Methods Pieces of organ cultures of human skin were used as a model to assess the biological effects of UVB irradiation and the protective effect of topical application of two Extreme preparations. Skin pieces were analyzed for mitochondrial activity by MTT assay, for apoptosis by caspase 3 assay, and for cytokine secretion by solid phase ELISA. Human subjects were tested to evaluate the effect of Extreme preparations on skin wrinkle depth using PRIMOS and skin hydration by a corneometer. Results UVB irradiation induced cell apoptosis in the epidermis of skin organ cultures and increased their pro‐inflammatory cytokine, tumor necrosis α (TNFα) secretion. Topical applications of both preparations significantly attenuated all these effects. Furthermore, in human subjects, a reduction in wrinkle depth and an elevation in the intense skin moisture were observed. Conclusions The observations clearly show that EXD and EXN preparations have protective anti‐apoptotic and anti‐inflammatory properties that can attenuate biological effects of skin photo‐damage. Topical application of the preparations improves skin appearance by reducing its wrinkles depth and increasing its moisturizing impact.