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In the shadow of the wrinkle: experimental models
Author(s) -
Humbert Philippe,
Viennet Céline,
Legagneux Kévin,
Grandmottet François,
Robin Sophie,
Muret Patrice
Publication year - 2012
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/j.1473-2165.2011.00601.x
Subject(s) - photoaging , wrinkle , skin aging , human skin , in vitro , in vivo , animal model , pig skin , dermatology , medicine , biology , biomedical engineering , gerontology , biochemistry , genetics , microbiology and biotechnology , endocrinology
Summary Research on aging has run for decades, and knowledge on the biologic process of skin chronological and photoaging is still increasing thanks to read across results generated between human, animal, and in vitro studies. However, wrinkles should not be considered to result only from the aging process. There are few reports on specific wrinkle histological features compared to the surrounding skin, and there is thus a need in really wrinkling skin animal and in vitro models. UV‐irradiated Hr mouse is a good model because it develops wrinkles. Nevertheless, as mouse skin is somehow different from human skin, the innovative model of wrinkling human skin xenograft on SCID mice seems to be really promising. Concerning in vitro and ex vivo models, although there have been considerable advances in reconstructing realistic aged skins, there is still a lack of in vitro wrinkling skin model, and unfortunately, this gap will probably be difficult to fill.