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Efficacy of a novel hydroquinone‐free skin‐brightening cream in patients with melasma
Author(s) -
Gold Michael H,
Biron Julie
Publication year - 2011
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/j.1473-2165.2011.00573.x
Subject(s) - melasma , dermatology , medicine , washout , skin whitening , skin color , hydroquinone , sensitive skin , chemistry , active ingredient , pharmacology , organic chemistry , artificial intelligence , computer science
Summary Background For treating irregular skin pigmentation, a hallmark of premature skin aging, safe and effective alternatives to hydroquinone and kojic acid are being researched. Aims Four skin‐brightening actives targeting melanin formation at multiple levels, namely disodium glycerophosphate, L‐leucine, phenylethyl resorcinol, and undecylenoyl phenylalanine, in an oil‐in‐water emulsion cream were evaluated. Patients/Methods Twenty female patients with mild‐to‐moderate epidermal melasma were included. After a washout period of 1 month with a sunscreen, they continued using the sunscreen and added the novel skin‐brightening cream for 12 weeks twice daily to entire face. Results Whereas there was no significant change in skin pigmentation during the washout, signs for uneven skin tone including melasma area and severity and appearance of lentigines significantly decreased by up to 43% after the 12‐week treatment period with the skin‐brightening cream. The skin‐brightening complex is well tolerated, which should allow its continued use over a prolonged period of time, in particular, when comparing skin‐brightening approaches with exfoliating or peeling agents. Conclusions When used with a daily sunscreen, the skin‐brightening complex represents a valuable alternative to hydroquinone products and can be used for maintenance or adjunct skin care with lightening therapies.