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Modification of skin discoloration by a topical treatment containing an extract of Dianella ensifolia : a potent antioxidant
Author(s) -
Mammone Thomas,
Muizzuddin Neelam,
Declercq Lieve,
Clio Dominique,
Corstjens Hugo,
Sente Ilse,
Van Rillaer Katrin,
Matsui Mary,
Niki Yoko,
Ichihashi Masamitsu,
Giacomoni Paolo U.,
Yarosh Dan
Publication year - 2010
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/j.1473-2165.2010.00491.x
Subject(s) - antioxidant , chemistry , dpph , hyperpigmentation , hydroquinone , radical , skin hyperpigmentation , skin whitening , in vivo , dermatology , pharmacology , active ingredient , organic chemistry , biochemistry , medicine , biology , microbiology and biotechnology
Summary Skin hyperpigmentation, and the reactions that precipitate it, have been linked to free radicals by the fact that free radical scavengers or antioxidants can slow that hyperpigmentation. We have screened several hundred plant extracts for antioxidants and discovered one that is both a strong antioxidant and can reduce skin hyperpigmentation. Extracts of Dianella ensifolia contain 1‐(2,4‐dihydrophenyl)‐3‐(2,4‐dimethoxy‐3‐methylphenyl) propane (DP), which was found to inhibit the free radical 1‐1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) with an EC 50 value of 78 μ m . DP was also found to inhibit Ultraviolet (UV)C‐induced lipid oxidation with an EC 50 of about 30 μ m . We next investigated the effects of this antioxidant on skin hyperpigmentation. The reduction of discoloration by different topical treatments has been assessed in human volunteers using an in vivo assay for the rate of fading of UVB‐induced tan. Two pharmaceutical formulas containing 4% hydroquinone (HQ) were used as positive controls, and we tested the ability of DP, a plant‐derived amphoteric antioxidant, to increase performance of non‐HQ cosmetic formulations. We found that the cosmetic formula containing DP produced an increase in the rate of fading compared to the two pharmaceutical treatments containing HQ.