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Topical atropine sulfate for the treatment of axillary hyperhidrosis
Author(s) -
Grimalt Ramon,
Tordera Patricia Domínguez,
Callejas Marco A
Publication year - 2006
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/j.1473-2165.2006.00273.x
Subject(s) - atropine sulfate , atropine , hyperhidrosis , medicine , anticholinergic , anesthesia , axilla , dermatology , surgery , cancer , breast cancer
Summary Background Axillary hyperhidrosis does not have a low‐cost, free of secondary effects, satisfactory treatment. Eccrine hidrocystomas have been successfully treated with topical atropine solution. Hypothesis Axillary hyperhidrosis could respond to the topical application of atropine solution. Methods Ten patients were selected. Eight with mild pure primary axillary hyperhidrosis and two with compensatory sweating after sympacthectomy. One milliliter of a water solution of atropine sulfate at 1% was applied twice a day over the affected area and massaged for 30 s. Treatment was maintained for 15 days. The results were rated using a scale from 1 to 10 of satisfaction. Results Only 2 of the 10 treated patients responded partially to the topical application of atropine sulfate. No local or systemic secondary effects were observed. Conclusions The results of the study demonstrated that focal hyperhidrosis does not improve after the local application of anticholinergic drugs such as atropine sulfate.