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Therapeutic implications of small interfering RNA in cardiovascular diseases
Author(s) -
Raghunathan Suchi,
Patel Bhoomika M.
Publication year - 2013
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2012.01051.x
Subject(s) - small interfering rna , rna , disease , mediator , mechanism (biology) , rna silencing , population , bioinformatics , medicine , rna interference , intensive care medicine , biology , gene , environmental health , genetics , philosophy , epistemology
Cardiovascular diseases ( CVD s) place a heavy burden on the economies of low‐ and middle‐income countries. Comprehensive action requires combining approaches that seek to reduce the risks throughout the entire population with strategies that target individuals at high risk or with established disease. Small interfering RNA (si RNA ) as a functional mediator for regulation of gene expression has been evaluated for potential therapeutic targets for the treatment of various cardiovascular diseases such as hypertension, atherosclerosis, heart failure etc. The present review attempts have been made to provide a brief outline of the current understanding of the mechanism of RNA i and the delivery system and describe the therapeutic application of si RNA s and their potential for treating CVD s which are taking a heavy toll on human life.