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Daphnetin prevents chronic unpredictable stress‐induced cognitive deficits
Author(s) -
Liao MinJing,
Lin LianFeng,
Zhou Xing,
Zhou XiaoWen,
Xu Xiao,
Cheng Xin,
Gao Qin,
Luo HuanMin
Publication year - 2013
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2012.01049.x
Subject(s) - chronic stress , cognition , in vivo , mood , neuroscience , effects of sleep deprivation on cognitive performance , medicine , pharmacology , endocrinology , psychology , biology , clinical psychology , microbiology and biotechnology
Chronic exposure to stress hormones might impair cognitive functions such as learning and memory, which were associated with many mood disorders and neurodegenerative diseases. In this study, we aimed to screen for effective compounds to prevent cognitive deficits induced by chronic stress. Daphnetin was found to protect the cortical neurons against dexamethasone‐induced reduction of cell viability in a dose‐dependent manner in vitro. We further evaluated its effects on chronic unpredictable stress ( CUS ) mice in vivo. Two and 8 mg/kg administration of daphnetin could improve the performance of stress mice in M orris water maze tests and forced swimming tests. The results suggested that daphnetin might be a potent compound to treat cognitive deficits induced by CUS .