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W nt‐4 potently inhibits capillary outgrowth from rat aorta in 3 D culture
Author(s) -
Jover Bernard,
Girardot Daphné,
Courtois Roy de Vacquières Françoise,
Casellas Daniel,
Molès JeanPierre
Publication year - 2013
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2012.01044.x
Subject(s) - wnt signaling pathway , microbiology and biotechnology , extracellular matrix , ex vivo , angiogenesis , cell growth , in vitro , extracellular , cell culture , chemistry , in vivo , lrp5 , biology , signal transduction , biochemistry , cancer research , genetics
Regulation of angiogenesis involves tight cell‐to‐cell and cell‐to‐extracellular‐matrix interactions. Various reports demonstrate that the W nt signaling pathways participate in this regulation. Using a three‐dimensional aortic ring culture combined with an ex vivo retroviral infection approach, we evaluated the effects of two W nt growth factors, W nt‐1 and W nt‐4, on the formation and growth of new capillaries. Our results show that W nt‐1 had no effect, whereas W nt‐4 was a potent inhibitor of capillary outgrowth in vitro .
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