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Design and methodology of POWER, an open‐label observation of the effect of primary care interventions on total cardiovascular risk in patients with hypertension
Author(s) -
De Backer Guy,
Petrella Robert J.,
Goudev Assen R.,
Radaideh Ghazi A.,
Rynkiewicz Andrzej,
Pathak Atul
Publication year - 2013
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2011.01006.x
Subject(s) - medicine , primary care , psychological intervention , intensive care medicine , family medicine , nursing
This article describes the design and methodology of the POWER study (Physicians’ Observational Work on Patient Education According to their Vascular Risk). POWER is an open‐label multinational postmarketing study of the angiotensin II‐receptor blocker eprosartan. The Systemic Coronary Risk Evaluation (SCORE) model has been used to estimate total cardiovascular risk and changes in total cardiovascular risk status during treatment for patients recruited in all countries other than Canada. Framingham Heart Study equations have been used to estimate risk in the Canadian contingent of POWER. Observations from POWER will provide insights into how clinicians try to achieve blood pressure goals within the framework of total cardiovascular risk management and how they integrate their treatment of blood pressure with other interventions. Experience during the POWER study may also help to affirm the utility, practicability and perhaps limitations of the SCORE system for estimating total cardiovascular risk and identify ways to improve the acceptance and implementation of risk estimation methods in cardiovascular primary prevention.