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Pharmacogenetics and pharmacogenomics of thienopyridines: clinically relevant?
Author(s) -
Close Sandra L.
Publication year - 2012
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2011.00983.x
Subject(s) - prasugrel , pharmacogenetics , thienopyridine , clopidogrel , pharmacogenomics , medicine , context (archaeology) , cyp2c19 , active metabolite , pharmacodynamics , pharmacology , cyp2d6 , prodrug , ticlopidine , pharmacokinetics , cytochrome p450 , biology , genotype , aspirin , paleontology , metabolism , gene , biochemistry
Pharmacogenetics have been touted as the future of personalized medicine where genetic biomarkers will guide therapeutic approach. The currently approved thienopyridines, prasugrel and clopidogrel, are prodrugs requiring conversion to active metabolite through the cytochrome P450 system. Genetic variation has been associated with the pharmacokinetic, pharmacodynamic, and clinical response to clopidogrel, but not to prasugrel. This review aims to summarize the recent pharmacogenetic findings associated with the response to thienopyridine treatment. Additionally, considerations for the incorporation of genetic biomarkers into clinical practice will be discussed in the context of thienopyridines.