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Rivaroxaban for the prevention and treatment of venous thromboembolism
Author(s) -
Turpie Alexander G.G.
Publication year - 2012
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2011.00980.x
Subject(s) - rivaroxaban , medicine , apixaban , fondaparinux , dabigatran , intensive care medicine , venous thromboembolism , knee replacement , clinical practice , thrombosis , surgery , warfarin , atrial fibrillation , physical therapy , arthroplasty
Venous thromboembolism (VTE) is a common and often life‐threatening cardiovascular disorder. Patients undergoing total hip replacement or total knee replacement surgery are at increased risk of VTE. In this setting, clinical practice guidelines recommend the use of low molecular weight heparins, vitamin K antagonists or fondaparinux for the prevention of VTE. However, the use of these anticoagulants is beset by practical difficulties that reduce compliance to therapy and adherence to recommended guidelines. New oral anticoagulants (OACs) that are administered in fixed doses without the need for monitoring are now being introduced to clinical practice. Rivaroxaban, dabigatran and apixaban are either approved or in advanced stages of clinical development for the prevention and/or treatment of VTE. This article provides an overview of the phase III clinical development programmes for these novel OACs, with special focus on rivaroxaban. With encouraging data already emerging, the promise of a simplified single‐drug approach for VTE treatment is on the horizon.