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Systemic lupus erythematosus induced by interferon β1 therapy in a patient with multiple sclerosis
Author(s) -
Bahri Dalila Mrabet,
Khiari Hela,
Essouri Asma,
Laadhar Lilia,
Zaraa Ines,
Mrabet Amel,
Meddeb Nihel,
Sellami Slaheddine
Publication year - 2012
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2011.00929.x
Subject(s) - medicine , multiple sclerosis , myalgia , synovitis , lupus erythematosus , systemic lupus erythematosus , immunology , interferon , dermatology , drug , rheumatoid arthritis , disease , pharmacology , antibody
Drug‐induced lupus erythematosus is defined as a lupus‐like syndrome temporally related to a drug exposure. We report a 34‐year‐old woman with multiple sclerosis who developed, while being treated with interferon β‐1a, myalgia and associated with wrist synovitis. Clinical and immunologic investigations were in favor of systemic lupus erythematosus. Interferon therapy was maintained. Under corticosteroids and antipaludeen treatment, the patient did not develop any other lupic manifestations.