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Sildenafil attenuates TNBS‐induced colitis in rats: possible involvement of cGMP and K ATP channels
Author(s) -
Fakhfouri Gohar,
Rahimian Reza,
Hashemi Saeed,
Rasouli Mohammad Reza,
Bahremand Arash,
Mehr Shahram Ejtemaei,
Khorramizadeh Mohammad Reza,
Dehpour Ahmad Reza
Publication year - 2012
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2011.00928.x
Subject(s) - glibenclamide , sildenafil , potassium channel , pharmacology , chemistry , colitis , atp sensitive potassium channel , potassium , potassium channel opener , endocrinology , medicine , organic chemistry , diabetes mellitus
The involvement of cGMP/K ATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP‐sensitive potassium channels (K ATP ) and cGMP, respectively.