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Factitious increases in serum testosterone concentrations related to phenylbutazone therapy
Author(s) -
Uzzan Bernard,
DumontFischer Dominique,
Lahlou Najiba,
Bihan Hélène,
Boissier MarieChristophe,
Alvarez JeanClaude,
Perret GérardYves,
Cohen Régis
Publication year - 2008
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2007.00564.x
Subject(s) - phenylbutazone , testosterone (patch) , endocrinology , medicine , drug , hormone , drug interaction , pharmacology , chemistry
We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications.