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Glitazones in the treatment of diabetes mellitus: clinical outcomes in large scale clinical trials
Author(s) -
Charbonnel Bernard
Publication year - 2007
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2007.00533.x
Subject(s) - diabetes mellitus , medicine , clinical trial , scale (ratio) , intensive care medicine , physical therapy , endocrinology , physics , quantum mechanics
Only one large scale cardiovascular outcome study has been completed and published for the thiazolidines‐iones in type 2 diabetes, the PROactive study which demonstrates a strong trend in favour of a specific cardioprotective effect of pioglitazone. The other available data, published as meta‐analyses, suggest that there is a difference in this regard between pioglitazone and rosiglitazone.