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Effect of chronic chromium picolinate in animal models of anxiety and memory
Author(s) -
Khanam Razia,
Pillai K.K.
Publication year - 2007
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2007.00503.x
Subject(s) - elevated plus maze , anxiolytic , anxiety , serotonergic , spontaneous alternation , medicine , diabetes mellitus , depression (economics) , t maze , endocrinology , psychology , serotonin , psychiatry , hippocampus , macroeconomics , receptor , economics
Diabetes mellitus is associated with certain neurological problems such as depression, anxiety, memory impairment, etc. As chromium picolinate (CrP), a widely used trace element is shown to have beneficial effects in diabetes and depression, we investigated its effects on elevated plus maze and spontaneous alternation behavior paradigm as a measure of anxiety and memory, respectively. CrP (8 μ g/mL in drinking water) significantly increased percentage preference to open arm in elevated plus maze in diabetic and normal rats. However, no significant changes were observed in percentage alternation after CrP chronic treatment. The possible anxiolytic effect of CrP might be related to its effect on serotonergic transmission.