Premium
Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature
Author(s) -
Roussin Anne,
Montastruc JeanLouis,
LapeyreMestre Maryse
Publication year - 2007
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2007.00497.x
Subject(s) - propofol , sedation , medicine , intensive care medicine , recreational drug , anesthesia , drugs of abuse , pharmacology , drug
Propofol (2,6‐diisopropylphenol) is an intravenous short‐acting anaesthetic widely used for inducing and maintaining anaesthesia. Propofol is also being increasingly used for sedation. Beside medical use, propofol is abused for recreational purpose, mostly in medical professionals who are not informed of the risk of dependence to this compound. The aim of this review was to provide an overview of molecular, animal and clinical pharmacological data of the literature evidencing the potential for abuse and dependence of propofol.