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Activities of Z ‐ajoene against tumour and viral spreading in vitro
Author(s) -
Terrasson Jerome,
Xu Bo,
Li Min,
Allart Sophie,
Davig JeanLuc,
Zhang Lihe,
Wang Kui,
Davrinche Christian
Publication year - 2007
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2007.00470.x
Subject(s) - in vitro , downregulation and upregulation , apoptosis , cd8 , biology , microbiology and biotechnology , proteasome , gene , virology , cancer research , immunology , biochemistry , immune system
Z ‐ajoene is a garlic‐derived compound with known anti‐tumour properties. This report argues in favour of pro‐apoptotic and cell cycle blockage activities of Z ‐ajoene on various cell lines involving activation of the p53‐family gene products, p53, p63 and p73, at indicated doses. According to its known anti‐proteasome activity, Z ‐ajoene induced a downregulation of MHC‐class I expression at the surface of treated cells but did not impair their recognition by CD8 + T cells. We further demonstrated a new activity of Z ‐ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. Altogether our data point at the ubiquitous efficiency of Z ‐ajoene as a new compound to fight against cancers of various origins including those that put up viruses.