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Prevention of sudden cardiac death by n‐3 polyunsaturated fatty acids
Author(s) -
Leaf Alexander
Publication year - 2006
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2006.00438.x
Subject(s) - polyunsaturated fatty acid , sudden cardiac death , fish oil , medicine , sudden death , clinical trial , coronary heart disease , observational study , disease , docosahexaenoic acid , fish <actinopterygii> , physiology , cardiology , fatty acid , biology , biochemistry , fishery
There were already several epidemiologic studies that showed eating fish frequently seemed to reduce deaths from coronary heart disease. There were also observational and clinical trials, which more specifically showed that the reduction in cardiovascular deaths from eating fish were largely the result of n‐3 polyunsaturated fatty acids in fish oil for the prevention of sudden cardiac death (SCD). This led me to perform a clinical trial in which all subjects had an implanted cardioverter–defibrillator and were at very high risk of SCD. The results of this study and the mechanisms by which the n‐3 fish oil fatty acids prevent fatal cardiac arrhythmias will be the subject of this review.