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How to deal with multiple endpoints in clinical trials
Author(s) -
Neuhäuser Markus
Publication year - 2006
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2006.00437.x
Subject(s) - bonferroni correction , multiple comparisons problem , intersection (aeronautics) , clinical trial , statistical hypothesis testing , medicine , clinical endpoint , econometrics , statistics , mathematics , medical physics , engineering , aerospace engineering
Multiple endpoints are common in clinical trials. This article discusses statistical methods that can be applied to control the rate of false positive conclusions at an acceptable level. The considered methods include the Bonferroni adjustment and related methods, the intersection‐union test, ordered hypotheses and gatekeeper procedures, composite endpoints and global assessment measures, closed testing procedures, and combinations of different approaches.