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Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs
Author(s) -
Létienne Robert,
Bel Lydia,
Bessac AnneMarie,
Denais Delphine,
Degryse AnneDominique,
John Gareth W.,
Grand Bruno
Publication year - 2006
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2006.00394.x
Subject(s) - myoglobin , cardiology , medicine , myocardial infarction , troponin , troponin i , cardioprotection , ischemia , chemistry , biochemistry
Abstract The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60‐min and then reperfused for 48‐h. Plasma levels of myoglobin and troponin I were quantified during reperfusion. Vehicle or cariporide (2.5 mg/kg) were administered i.v. before ischaemia and infused throughout ischaemia and for the beginning of reperfusion. In vehicle‐treated pigs, the infarct size represented 26% ± 3% of the area at risk. Cariporide significantly decreased the infarct size by 66% ± 9%, and significantly reduced plasma levels of myoglobin and troponin I. A strongly correlated linear relationship between myocardial necrosis and plasma levels of myoglobin ( R = 0.966, P < 0.0001) or troponin I ( R = 0.855, P < 0.0001) was clearly identified. In conclusion, in our porcine model of myocardial infarction, even with small infarcts (in the presence of cariporide), plasma levels of myoglobin and troponin I are predictive of the presence of necrosis and its extent.