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Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task
Author(s) -
Vohora Divya,
Pal Shanthi N.,
Pillai K.K.
Publication year - 2005
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2005.00359.x
Subject(s) - tacrine , thioperamide , spontaneous alternation , alternation (linguistics) , task (project management) , parasympatholytic , t maze , psychology , medicine , neuroscience , chemistry , antagonist , hippocampus , muscarinic acetylcholine receptor , histamine h3 receptor , receptor , biochemistry , linguistics , philosophy , management , economics , acetylcholinesterase , enzyme
A combination of sub‐effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test.