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Influence of landiolol on the dose requirement of propofol for induction of anesthesia
Author(s) -
Takizawa Daisuke,
Saito Shigeru,
Sato Eri,
Hiraoka Haruhiko,
Kunimoto Fumio,
Goto Fumio
Publication year - 2005
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2005.00351.x
Subject(s) - propofol , anesthesia , medicine
It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short‐acting beta‐1‐adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control and landiolol group. Induction of anesthesia commenced 10 min after the infusion of 0.9% saline or landiolol, using a Diprifusor set to achieve propofol plasma concentration of 6.0 μ g/mL. Induction of anesthesia was defined as the first lack of response to command. Propofol dose was 2.22 ± 0.21 mg/kg for the control group and 1.79 ± 0.28 mg/kg for the landiolol group ( P < 0.0001). The quantity of propofol required for the induction of anesthesia was reduced by the administration of landiolol.