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Sedation in children undergoing CT scan or MRI: effect of time‐course and tolerance of rectal chloral hydrate
Author(s) -
Treluyer JeanMarc,
Andre Christine,
Carp PierreFrançois Ceccaldi,
Chalumeau Martin,
Tonnelier Sylvie,
Cuq Cédric,
Kalifa Gabriel,
Pons Gérard,
Adamsbaum Catherine
Publication year - 2004
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.2004.00232.x
Subject(s) - chloral hydrate , sedation , anesthesia , medicine
The aim of this paper was to describe the time‐course of the sedative effect of rectal chloral hydrate (75 mg/kg) in children undergoing CT scan or MRI. Twenty children (2.13 ± 1.43 years old) were administered 75 mg/kg chloral hydrate rectally (chloralhydrat‐rectiole rectal formulation, Dr Mann‐Pharma Lab, Berlin, Germany), before a CT scan or an NMR imaging. Sedation was measured at specific times using a sedation score of 1–6. Patients were continuously monitored for respiratory and heart rate, systolic and diastolic blood pressures, and oxygen saturation. About 82.35 and 94.11% of the patients had a score of sedation ≥ 3 within 15 and 30 min, respectively. The mean time to effective sedation (score ≥ 3) was of 0.30 ± 0.14 h (median time, 0.25 h). The mean duration of effective sedation (score ≥ 3) was 1.29 ± 1.05 h (median duration, 0.75 h). A total of 93.1% of the X‐ray sections were obtained without artifact and sedation was considered by radiologists to be efficient for 83.3% of the procedures. This sedation procedure appeared efficient and safe during ambulatory CT scan and NMR imaging. The long‐term effect of chloral hydrate, however, remains to be evaluated.