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Antagonism by pimozide of olanzapine‐induced hypothermia
Author(s) -
Ninan Ipe,
Kulkarni Shrinivas K.
Publication year - 1999
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1999.tb00359.x
Subject(s) - pimozide , apomorphine , agonist , dopamine antagonist , pharmacology , hypothermia , endocrinology , dopamine receptor d2 , sch 23390 , olanzapine , chemistry , medicine , dopamine receptor , partial agonist , dopamine , haloperidol , receptor , schizophrenia (object oriented programming) , psychiatry
— The atypical antipsychotic olanzapine (2.5–20 mg/kg) produced hypothermia in rats. The decrease in rectal temperature caused by olanzapine (2.5–20 mg/kg) was blocked by the selective dopamine D 2 receptor antagonist pimozide (0.5 and 1 mg/kg) but not by the dopamine D 1 receptor antagonist SCH 23390 (0.5 and 1 mg/kg). The dopamine D 1 /D 2 receptor agonist apomorphine (3 mg/kg) and the selective dopamine D 2 receptor agonist talipexole (0.5 mg/kg) produced hypothermia in rats. Olanzapine (10 and 20 mg/kg) significantly blocked hypothermia produced by both apomorphine and talipexole while the lower doses (2.5 and 5 mg/kg) of olanzapine failed to block it. The present results demonstrate that olanzapine behaves as a partial agonist at brain DA D 2 receptor populations involved in thermoregulation in the rat.