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Effects of tramadol on experimental inflammation
Author(s) -
Bianchi Mauro,
Rossoni Giuseppe,
Sacerdote Paola,
Panerai Alberto E.
Publication year - 1999
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1999.tb00342.x
Subject(s) - tramadol , inflammation , exudate , hyperalgesia , pharmacology , analgesic , leukotriene b4 , prostaglandin , nociception , edema , medicine , immune system , chemistry , eicosanoid , subcutaneous injection , immunology , biochemistry , enzyme , pathology , receptor , arachidonic acid
— We examined the ability of the analgesic drug tramadol to affect the development of inflammation in rats. The acute administration of tramadol significantly reduced the edema and the hyperalgesia induced by yeast injection in the paw. Moreover, in the subcutaneous carrageenin‐induced inflammation, tramadol reduced the amount of the exudate, as well as the prostaglandin (PG)E 2 ‐like bio‐ and immuno‐activity in the exudate; on the contrary, leukotriene (LT)B 4 concentrations in the exudate were not changed. However, tramadol did not affect the ability of macrophages to migrate towards the chemotactic peptide N‐formyl‐L‐methionil‐L‐leucyl‐L‐phenylalanine (FMLP). Our results suggest that tramadol is able to inhibit the development of different types of inflammation in the rat without affecting immune mechanisms, and contribute to explain the efficacy of this drug in the treatment of inflammatory pain.